Venue: Estadio de Mestalla, Valencia
Kick-off: 08:00 PM GMT / 03:00 PM EST
Marc-Andre ter Stegen did not have much to do in the first leg against Valencia and with Barcelona currently holding a whopping seven goal advantage; the German goalkeeper can head into the return leg without any pressure whatsoever.
Nonetheless, ter Stegen is keen on impressing in each game as he looks to become the number one choice in La Liga as well and the 23-year old will undoubtedly want to keep a clean sheet on the night.
At the back, regulars Jordi Alba, Gerard Pique, Javier Mascherano and Dani Alves are all expected to be given a well deserved rest during the clash and the fringe players should get their opportunity to start.
It looks like Thomas Vermaelen and Marc Bartra will be lining up in central defence while the full back positions is likely to be occupied by the duo of Jeremy Mathieu and Aleix Vidal.
Douglas Pereira has hardly featured for Barcelona this season and he might well also get a look-in during the clash.
Sergio Busquets was rested in the clash against Levante and this means that the Spanish international could well get a start on Wednesday night alongside the ever impressing Sergi Roberto.
Ivan Rakitic and Andres Iniesta are likely to be handed rests against Valencia while Arda Turan could start after not featuring during the win over Levante.
Enrique could also use the game to hand the likes of Gerard Gumbau, Sergi Samper and Juan Cámara a chance to feature for the first team.
Lionel Messi is certain to miss the clash due to a stomach injury while Neymar and Luis Suarez are also unlikely to be used on the night by Enrique. Instead, young star Munir and Sandro Ramirez are set to be provided an opportunity to impress while Adriano should also be handed a rare start.
Barcelona Probable Lineup: ter Stegen; Vidal, Vermaelen, Bartra, Mathieu; Sergi Roberto, Busquets, Turan; Adriano, Munir, Sandro Ramirez